Clinical and genetic characteristics in a group of 45 patients with Turner syndrome (monocentric study)
Identifieur interne : 000712 ( Main/Exploration ); précédent : 000711; suivant : 000713Clinical and genetic characteristics in a group of 45 patients with Turner syndrome (monocentric study)
Auteurs : Simona Bucerzan [Roumanie] ; Diana Miclea [Roumanie] ; Radu Popp [Roumanie] ; Camelia Alkhzouz [Roumanie] ; Cecilia Lazea [Roumanie] ; Ioan Victor Pop [Roumanie] ; Paula Grigorescu-Sido [Roumanie]Source :
- Therapeutics and Clinical Risk Management [ 1176-6336 ] ; 2017.
Abstract
Recent years have seen a shift in perspective on Turner syndrome, as it is no longer considered a significant disability due to therapeutic advances. The delay of diagnosis and the underdiagnosis are common in Turner syndrome, especially because of the great phenotypic variability and lack of firm diagnostic criteria.
Our first aim was to assess the clinical and the cytogenetic characteristics and growth rate in growth hormone (GH)-treated patients as compared to those with spontaneous growth. The second aim was to analyze the Y chromosomal sequences.
We analyzed 45 patients diagnosed with Turner syndrome in Genetic Pathology Centre of Cluj Emergency Children’s Hospital. We carried out a study of the clinical features, the correlations between the karyotype and the phenotype, and we also made a research of Y chromosome sequences.
The average age at diagnosis was 8.9±5.4 years. A significant association was observed between the number of external phenotypical abnormalities and internal malformations (
The importance of this study resides, to the best of our knowledge, in the fact that the largest group of patients in Romania was analyzed and assessed. To draw firm conclusions on the most valuable clinical indicators for Turner syndrome diagnosis in clinical practice, studies on large groups of patients should be conducted.
Url:
DOI: 10.2147/TCRM.S126301
PubMed: 28496331
PubMed Central: 5422538
Affiliations:
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uniqKey="Grigorescu Sido P" first="Paula" last="Grigorescu-Sido">Paula Grigorescu-Sido</name><affiliation wicri:level="1"><nlm:aff id="af1-tcrm-13-613">Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28496331</idno><idno type="pmc">5422538</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422538</idno><idno type="RBID">PMC:5422538</idno><idno type="doi">10.2147/TCRM.S126301</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">004647</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004647</idno><idno 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Bucerzan</name><affiliation wicri:level="1"><nlm:aff id="af1-tcrm-13-613">Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Miclea, Diana" sort="Miclea, Diana" uniqKey="Miclea D" first="Diana" last="Miclea">Diana Miclea</name><affiliation wicri:level="1"><nlm:aff id="af1-tcrm-13-613">Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af2-tcrm-13-613">Department of Molecular Sciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Molecular Sciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Popp, Radu" sort="Popp, Radu" uniqKey="Popp R" first="Radu" last="Popp">Radu Popp</name><affiliation wicri:level="1"><nlm:aff id="af2-tcrm-13-613">Department of Molecular Sciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Molecular Sciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Alkhzouz, Camelia" sort="Alkhzouz, Camelia" uniqKey="Alkhzouz C" first="Camelia" last="Alkhzouz">Camelia Alkhzouz</name><affiliation wicri:level="1"><nlm:aff id="af1-tcrm-13-613">Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Lazea, Cecilia" sort="Lazea, Cecilia" uniqKey="Lazea C" first="Cecilia" last="Lazea">Cecilia Lazea</name><affiliation wicri:level="1"><nlm:aff id="af1-tcrm-13-613">Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Pop, Ioan Victor" sort="Pop, Ioan Victor" uniqKey="Pop I" first="Ioan Victor" last="Pop">Ioan Victor Pop</name><affiliation wicri:level="1"><nlm:aff id="af2-tcrm-13-613">Department of Molecular Sciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Department of Molecular Sciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author><author><name sortKey="Grigorescu Sido, Paula" sort="Grigorescu Sido, Paula" uniqKey="Grigorescu Sido P" first="Paula" last="Grigorescu-Sido">Paula Grigorescu-Sido</name><affiliation wicri:level="1"><nlm:aff id="af1-tcrm-13-613">Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania</nlm:aff><country xml:lang="fr">Roumanie</country><wicri:regionArea>Emergency Hospital for Children, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca</wicri:regionArea><wicri:noRegion>Cluj-Napoca</wicri:noRegion></affiliation></author></analytic><series><title level="j">Therapeutics and Clinical Risk Management</title><idno type="ISSN">1176-6336</idno><idno type="eISSN">1178-203X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p>Recent years have seen a shift in perspective on Turner syndrome, as it is no longer considered a significant disability due to therapeutic advances. The delay of diagnosis and the underdiagnosis are common in Turner syndrome, especially because of the great phenotypic variability and lack of firm diagnostic criteria.</p></sec><sec><title>Aim</title><p>Our first aim was to assess the clinical and the cytogenetic characteristics and growth rate in growth hormone (GH)-treated patients as compared to those with spontaneous growth. The second aim was to analyze the Y chromosomal sequences.</p></sec><sec><title>Materials and methods</title><p>We analyzed 45 patients diagnosed with Turner syndrome in Genetic Pathology Centre of Cluj Emergency Children’s Hospital. We carried out a study of the clinical features, the correlations between the karyotype and the phenotype, and we also made a research of Y chromosome sequences.</p></sec><sec><title>Results</title><p>The average age at diagnosis was 8.9±5.4 years. A significant association was observed between the number of external phenotypical abnormalities and internal malformations (<italic>r</italic>=0.45), particularly the cardiovascular ones (<italic>r</italic>=0.44). Patients treated with GH showed improvement in growth rate, with final stature significantly better than in untreated patients; benefits following treatment were greater if diagnosis was made before the age of 5 years. Thirteen percent of patients experienced spontaneous and complete puberty, whereas 30% experienced incomplete puberty. Patients with the 45,X genotype had a greater stature deficit and a higher incidence of cardiac malformations, compared with patients with 45,X/46,XX mosaic karyotype. Y chromosome sequences were found in only one patient, who subsequently underwent gonadectomy.</p></sec><sec><title>Conclusion</title><p>The importance of this study resides, to the best of our knowledge, in the fact that the largest group of patients in Romania was analyzed and assessed. To draw firm conclusions on the most valuable clinical indicators for Turner syndrome diagnosis in clinical practice, studies on large groups of patients should be conducted.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Davenport, Ml" uniqKey="Davenport M">ML Davenport</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cabrol, S" uniqKey="Cabrol S">S Cabrol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nwosu, Ec" uniqKey="Nwosu E">EC Nwosu</name></author><author><name sortKey="Brockbank, A" uniqKey="Brockbank A">A Brockbank</name></author><author><name sortKey="Walkinshaw, Sa" uniqKey="Walkinshaw S">SA Walkinshaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hovatta, O" uniqKey="Hovatta O">O Hovatta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massa, G" uniqKey="Massa G">G Massa</name></author><author><name sortKey="Verlinde, F" uniqKey="Verlinde F">F Verlinde</name></author><author><name sortKey="De Schepper, J" uniqKey="De Schepper J">J De Schepper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stochholm, K" uniqKey="Stochholm K">K Stochholm</name></author><author><name sortKey="Juul, S" uniqKey="Juul S">S Juul</name></author><author><name sortKey="Juel, K" uniqKey="Juel K">K Juel</name></author><author><name sortKey="Naeraa, Rw" uniqKey="Naeraa R">RW Naeraa</name></author><author><name sortKey="Gravholt, Ch" uniqKey="Gravholt C">CH Gravholt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hughes, Ip" uniqKey="Hughes I">IP Hughes</name></author><author><name sortKey="Choong, Cs" uniqKey="Choong C">CS Choong</name></author><author><name sortKey="Harris, M" uniqKey="Harris M">M Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davenport, Ml" uniqKey="Davenport M">ML Davenport</name></author><author><name sortKey="Crowe, Bj" uniqKey="Crowe B">BJ Crowe</name></author><author><name sortKey="Travers, Sh" uniqKey="Travers S">SH Travers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Backeljauw, P" uniqKey="Backeljauw P">P Backeljauw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bondy, Ca" uniqKey="Bondy C">CA Bondy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davenport, Ml" uniqKey="Davenport M">ML Davenport</name></author><author><name sortKey="Punyasavatsut, N" uniqKey="Punyasavatsut N">N Punyasavatsut</name></author><author><name sortKey="Stewart, Pw" uniqKey="Stewart P">PW Stewart</name></author><author><name sortKey="Gunther, Df" uniqKey="Gunther D">DF Gunther</name></author><author><name sortKey="S Vendahl, L" uniqKey="S Vendahl L">L Sävendahl</name></author><author><name sortKey="Sybert, Vp" uniqKey="Sybert V">VP Sybert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miclea, Dl" uniqKey="Miclea D">DL Miclea</name></author><author><name sortKey="Grigorescu Sido, P" uniqKey="Grigorescu Sido P">P Grigorescu-Sido</name></author><author><name sortKey="Bucerzan, S" uniqKey="Bucerzan S">S Bucerzan</name></author><author><name sortKey="Pop, Iv" uniqKey="Pop I">IV Pop</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manuel, M" uniqKey="Manuel M">M Manuel</name></author><author><name sortKey="Katayama, Pk" uniqKey="Katayama P">PK Katayama</name></author><author><name sortKey="Jones, Hwj" uniqKey="Jones H">HWJ Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verp, Ms" uniqKey="Verp M">MS Verp</name></author><author><name sortKey="Simpson, Jl" uniqKey="Simpson J">JL Simpson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reena Rahayu, Mz" uniqKey="Reena Rahayu M">MZ Reena Rahayu</name></author><author><name sortKey="Sharifah, Na" uniqKey="Sharifah N">NA Sharifah</name></author><author><name sortKey="Zubaidah, Z" uniqKey="Zubaidah Z">Z Zubaidah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nazmy, Na" uniqKey="Nazmy N">NA Nazmy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiktor, Ae" uniqKey="Wiktor A">AE Wiktor</name></author><author><name sortKey="Van Dyke, Dl" uniqKey="Van Dyke D">DL Van Dyke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rond N Lagos, Sm" uniqKey="Rond N Lagos S">SM Rondón Lagos</name></author><author><name sortKey="Rangel Jimenez, Ne" uniqKey="Rangel Jimenez N">NE Rangel Jiménez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bashamboo, A" uniqKey="Bashamboo A">A Bashamboo</name></author><author><name sortKey="Rahman, Mm" uniqKey="Rahman M">MM Rahman</name></author><author><name sortKey="Prasad, A" uniqKey="Prasad A">A Prasad</name></author><author><name sortKey="Padinjarel Chandy, S" uniqKey="Padinjarel Chandy S">S Padinjarel Chandy</name></author><author><name sortKey="Ahmad, J" uniqKey="Ahmad J">J Ahmad</name></author><author><name sortKey="Ali, S" uniqKey="Ali S">S Ali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sybert, Vp" uniqKey="Sybert V">VP Sybert</name></author><author><name sortKey="Mccauley, E" uniqKey="Mccauley E">E McCauley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elsheikh, M" uniqKey="Elsheikh M">M Elsheikh</name></author><author><name sortKey="Dunger, Db" uniqKey="Dunger D">DB Dunger</name></author><author><name sortKey="Conway, Gs" uniqKey="Conway G">GS Conway</name></author><author><name sortKey="Wass, Jah" uniqKey="Wass J">JAH Wass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gravholt, Ch" uniqKey="Gravholt C">CH Gravholt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saenger, P" uniqKey="Saenger P">P Saenger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cramer, Jw" uniqKey="Cramer J">JW Cramer</name></author><author><name sortKey="Bartz, Pj" uniqKey="Bartz P">PJ Bartz</name></author><author><name sortKey="Simpson, Pm" uniqKey="Simpson P">PM Simpson</name></author><author><name sortKey="Zangwill, Sd" uniqKey="Zangwill S">SD Zangwill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gotzsche, C" uniqKey="Gotzsche C">C Gotzsche</name></author><author><name sortKey="Krag Olsen, B" uniqKey="Krag Olsen B">B Krag-Olsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loscalzo, Ml" uniqKey="Loscalzo M">ML Loscalzo</name></author><author><name sortKey="Van, Pl" uniqKey="Van P">PL Van</name></author><author><name sortKey="Ho, Vb" uniqKey="Ho V">VB Ho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bondy, Ca" uniqKey="Bondy C">CA Bondy</name></author><author><name sortKey="Cheng, C" uniqKey="Cheng C">C Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Savendahl, L" uniqKey="Savendahl L">L Savendahl</name></author><author><name sortKey="Davenport, Ml" uniqKey="Davenport M">ML Davenport</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Even, L" uniqKey="Even L">L Even</name></author><author><name sortKey="Cohen, A" uniqKey="Cohen A">A Cohen</name></author><author><name sortKey="Marbach, N" uniqKey="Marbach N">N Marbach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sas, Tc" uniqKey="Sas T">TC Sas</name></author><author><name sortKey="De Muinck Keizer Schrama, Sm" uniqKey="De Muinck Keizer Schrama S">SM de Muinck Keizer-Schrama</name></author><author><name sortKey="Stijnen, T" uniqKey="Stijnen T">T Stijnen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pasquino, Am" uniqKey="Pasquino A">AM Pasquino</name></author><author><name sortKey="Passeri, F" uniqKey="Passeri F">F Passeri</name></author><author><name sortKey="Pucarelli, I" uniqKey="Pucarelli I">I Pucarelli</name></author><author><name sortKey="Segni, M" uniqKey="Segni M">M Segni</name></author><author><name sortKey="Municchi, G" uniqKey="Municchi G">G Municchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mohamed, S" uniqKey="Mohamed S">S Mohamed</name></author><author><name sortKey="Roche, Ef" uniqKey="Roche E">EF Roche</name></author><author><name sortKey="Hoey, Hm" uniqKey="Hoey H">HM Hoey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fernandes, S" uniqKey="Fernandes S">S Fernandes</name></author><author><name sortKey="Ventura, V" uniqKey="Ventura V">V Ventura</name></author><author><name sortKey="Doria, S" uniqKey="Doria S">S Doria</name></author><author><name sortKey="Barros, A" uniqKey="Barros A">A Barros</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sallai, A" uniqKey="Sallai A">A Sallai</name></author><author><name sortKey="S Lyom, J" uniqKey="S Lyom J">J Sólyom</name></author><author><name sortKey="Dobos, M" uniqKey="Dobos M">M Dobos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bianco, B" uniqKey="Bianco B">B Bianco</name></author><author><name sortKey="Lipay, M" uniqKey="Lipay M">M Lipay</name></author><author><name sortKey="Guedes, A" uniqKey="Guedes A">A Guedes</name></author><author><name sortKey="Oliveira, K" uniqKey="Oliveira K">K Oliveira</name></author><author><name sortKey="Verreschi, It" uniqKey="Verreschi I">IT Verreschi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsuchiya, K" uniqKey="Tsuchiya K">K Tsuchiya</name></author><author><name sortKey="Reijo, R" uniqKey="Reijo R">R Reijo</name></author><author><name sortKey="Page, Dc" uniqKey="Page D">DC Page</name></author><author><name sortKey="Disteche, Cm" uniqKey="Disteche C">CM Disteche</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Looijenga, Lh" uniqKey="Looijenga L">LH Looijenga</name></author><author><name sortKey="Stoop, H" uniqKey="Stoop H">H Stoop</name></author><author><name sortKey="De Leeuw, Hp" uniqKey="De Leeuw H">HP de Leeuw</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Roumanie</li></country></list><tree><country name="Roumanie"><noRegion><name sortKey="Bucerzan, Simona" sort="Bucerzan, Simona" uniqKey="Bucerzan S" first="Simona" last="Bucerzan">Simona Bucerzan</name></noRegion><name sortKey="Alkhzouz, Camelia" sort="Alkhzouz, Camelia" uniqKey="Alkhzouz C" first="Camelia" last="Alkhzouz">Camelia Alkhzouz</name><name sortKey="Grigorescu Sido, Paula" sort="Grigorescu Sido, Paula" uniqKey="Grigorescu Sido P" first="Paula" last="Grigorescu-Sido">Paula Grigorescu-Sido</name><name sortKey="Lazea, Cecilia" sort="Lazea, Cecilia" uniqKey="Lazea C" first="Cecilia" last="Lazea">Cecilia Lazea</name><name sortKey="Miclea, Diana" sort="Miclea, Diana" uniqKey="Miclea D" first="Diana" last="Miclea">Diana Miclea</name><name sortKey="Miclea, Diana" sort="Miclea, Diana" uniqKey="Miclea D" first="Diana" last="Miclea">Diana Miclea</name><name sortKey="Pop, Ioan Victor" sort="Pop, Ioan Victor" uniqKey="Pop I" first="Ioan Victor" last="Pop">Ioan Victor Pop</name><name sortKey="Popp, Radu" sort="Popp, Radu" uniqKey="Popp R" first="Radu" last="Popp">Radu Popp</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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